When you're developing code on a development server, anything goes: modifying the configuration, adding or upgrading Perl modules without checking that they are syntactically correct, not checking that Perl modules don't collide with other modules, adding experimental new modules from CPAN, etc. If something goes wrong, configuration changes can be rolled back (assuming you're using some form of version control), modules can be uninstalled or reinstalled, and the server can be started and stopped as many times as required to get it working.
Of course, if there is more than one developer working on a development server, things can't be quite so carefree. Possible solutions for the problems that can arise when multiple developers share a development server will be discussed shortly.
The most difficult situation is transitioning changes to a live server. However much the changes have been tested on a development server, there is always the risk of breaking something when a change is made to the live server. Ideally, any changes should be made in a way that will go unnoticed by the users, except as new or improved functionality or better performance. No users should be exposed to even a single error message from the upgraded service—especially not the "database busy" or "database error" messages that some high-profile sites seem to consider acceptable.
Live services can be divided into two categories: servers that must be up 24 hours a day and 7 days a week, and servers that can be stopped during non-working hours. The latter generally applies to Intranets of companies with offices located more or less in the same time zone and not scattered around the world. Since the Intranet category is the easier case, let's talk about it first.